After being infected with herpes, Joan Halprin, a single woman in her mid-thirties, feels untouchable. She spent her youth enjoying worldly experiences in New York and Paris, but now it's time to start a career as a copywriter for a Florida advertising agency. Fort Lauderdale in the 1980s is experiencing a real estate boom, and just as Joan's career is taking off, she falls for Nate, a client's handsome son. The moment she feared has arrived. Despite knowing that one in four women, and one in five men, is afflicted with the virus, how can Joan find the courage to tell Nate? Her irascible, rotund boss certainly isn't helping her regain self-esteem. But with her irrepressible humor, Joan concocts a bold creative solution. Too bold, perhaps, to work?